Open AccessProton Beam Therapy for Locally Recurrent Parotid Gland Cancer
Author(s) -
Yusuke Azami,
Yuichiro Hayashi,
Tatsuya Nakamura,
Kanako Kimura,
H. Yamaguchi,
Takashi Ono,
Kanako Takayama,
Katsumi Hirose,
Tomonori Yabuuchi,
Motohisa Suzuki,
Yoshiomi Hatayama,
Masato Hareyama,
Yasuhiro Kikuchi,
Nobukazu Fuwa
Publication year - 2016
Publication title -
indian journal of otolaryngology and head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 2231-3796
pISSN - 0973-7707
DOI - 10.1007/s12070-016-1008-y
Subject(s) - parotid gland , medicine , otorhinolaryngology , head and neck cancer , head and neck surgery , proton therapy , proton , cancer , beam (structure) , radiology , radiation therapy , pathology , surgery , optics , nuclear physics , physics
The aim of this study was to evaluate the efficacy and safety of proton beam therapy for patients with locally recurrent parotid cancer. Between 2009 and 2012, ten patients with locally recurrent parotid gland cancer were treated with proton beam therapy (70.2 Gy equivalents in 32 fractions) with or without intra-arterial infusion chemotherapy of cisplatin (50 mg/body/week, for a total of 5-8 weeks). The median follow-up was 24 months (range 10-49 months). The 1-year overall survival and local control rates were 80 %, and the 3-year overall survival and local control rates were 60 %. None of the patients experienced grade 3-5 toxicities in the treatment or the follow-up periods. These findings suggest that proton beam therapy could be applied effectively and safely for patients with locally recurrent parotid gland cancer.