Open AccessEvaluation of Liver Functions Based on Serum Aminotransferase Enzyme Levels in Patients with Obstructive Sleep Apnea Syndrome
Author(s) -
Doğan Atan,
Sabri Köseoğlu,
Kürşat Murat Özcan,
Aykut İkincioğulları,
Ayşe Betül Topak,
İbrahim Özcan,
Hüseyin Dere
Publication year - 2015
Publication title -
indian journal of otolaryngology and head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 2231-3796
pISSN - 0973-7707
DOI - 10.1007/s12070-015-0914-8
Subject(s) - medicine , obstructive sleep apnea , polysomnography , gastroenterology , alanine aminotransferase , otorhinolaryngology , apnea , surgery
Obstructive sleep apnea syndrome (OSAS) is associated with fatty liver disease. In the present study, relations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and the severity of OSAS and polysomnography parameters were investigated. The study included 194 patients with OSAS and 114 control patients. The patients underwent an overnight polysomnography (PSG) in the Sleep Laboratory. ALT and AST levels were compared between the patients and the controls and between the subgroups of the patients. ALT and AST levels were also compared with the PSG parameters REM AHI, NREM AHI and minimum O 2 saturation separately. The mean ALT was 28.95 in the patients and 17.85 in the controls ( p < 0.001) with a statistically significant difference and the mean AST was 23.62 in the patients and 16.53 in the controls with a statistically significant difference ( p < 0.001). The patients with OSAS had significantly higher ALT and AST levels. The higher the ALT and AST levels were, the more severe the disease was, though the differences between the subgroups of the patients were not significant.