Open AccessCell-free DNA in the surveillance of heart transplant rejection
Author(s) -
Dhruva Sharma,
Ganapathy Subramaniam,
Neha Sharma,
Pankaj Sharma
Publication year - 2021
Publication title -
indian journal of thoracic and cardiovascular surgery/indian journal of thoracic and cardiovascular surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 9
eISSN - 0973-7723
pISSN - 0970-9134
DOI - 10.1007/s12055-020-01130-9
Subject(s) - endomyocardial biopsy , heart transplantation , medicine , biopsy , transplantation , digital polymerase chain reaction , population , liquid biopsy , cell free fetal dna , polymerase chain reaction , intensive care medicine , oncology , pathology , cancer , biology , gene , biochemistry , environmental health , pregnancy , fetus , genetics , prenatal diagnosis
Circulating cell-free deoxyribonucleic acid (cfDNA) is promptly materializing as a highly useful tool for the surveillance of solid-organ transplant rejection. Donor-specific fraction (DF) cfDNA is a potential marker of selective donor organ injury. It is emerging as a promising analytical target in the near future. The aim of this systematic review is to throw light on the importance of cfDNA and future perspective in detecting acute rejection in heart transplantation.