Open AccessTransplantation for chemotherapy-induced cardiomyopathy—case series and review of current practice
Author(s) -
K. Balakrishnan,
Kemundel Genny Suresh Rao,
Ganapathy Subramaniam,
Dhruva Sharma
Publication year - 2020
Publication title -
indian journal of thoracic and cardiovascular surgery/indian journal of thoracic and cardiovascular surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 9
eISSN - 0973-7723
pISSN - 0970-9134
DOI - 10.1007/s12055-020-01018-8
Subject(s) - medicine , cardiotoxicity , cardiomyopathy , heart transplantation , trastuzumab , chemotherapy , breast cancer , sarcoma , dilated cardiomyopathy , doxorubicin , cardiac surgery , transplantation , oncology , cardiothoracic surgery , cancer , heart failure , vascular surgery , cardiology , surgery , pathology
Multimodality therapies have improved the survival after tumors like Ewing's sarcoma and breast cancer. However, cardiotoxicity following chemotherapy remains an important concern. We report a case series of four patients who presented to our heart team with severe dilated cardiomyopathy along with biventricular involvement. Two of the patients were females and had breast cancer for which they were treated with trastuzumab and had developed chemotherapy induced cardiomyopathy (CCMP). The other two patients were males who had Ewing's sarcoma who developed CCMP following treatment with doxorubicin.