Open AccessSynthesis of novel 2-(4-(2-morpholinoethoxy)phenyl)-N-phenylacetamide analogues and their antimicrobial study
Author(s) -
H. Jayadevappa,
G. Nagendrappa,
S. Umesh,
S. Chandrashekar
Publication year - 2012
Publication title -
journal of chemical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.32
H-Index - 52
eISSN - 0973-7103
pISSN - 0253-4134
DOI - 10.1007/s12039-012-0308-3
Subject(s) - antimicrobial , clotrimazole , chemistry , potency , streptomycin , agar , agar diffusion test , proton nmr , in vitro , stereochemistry , elemental analysis , combinatorial chemistry , nuclear chemistry , organic chemistry , microbiology and biotechnology , bacteria , escherichia coli , biochemistry , antifungal , biology , antibiotics , genetics , gene
A new class of potential biologically active 2-(4-(2-morpholinoethoxy)phenyl)-N-phenylacetamides has been synthesized from hydroxyphenylacetic acid. The products were characterized through IR, H-1 NMR, mass spectral studies and elemental analysis. The compounds were screened for antimicrobial activity by disc agar diffusion technique. The potency of compounds is tested against variety of fungal and bacterial strains in comparison to clotrimazole and streptomycin, respectively. Some of the synthesized compounds exhibit superior in vitro activity compared to the standard drugs
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