Open AccessClinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome
Author(s) -
Jordan M. Cloyd,
Yun Shin Chun,
Naruhiko Ikoma,
Jean Nicolas Vauthey,
T. Aloia,
Amanda Cuddy,
Miguel A. Rodrı́guez-Bigas,
YauTong You
Publication year - 2017
Publication title -
journal of gastrointestinal cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.473
H-Index - 47
eISSN - 1941-6628
pISSN - 1941-6636
DOI - 10.1007/s12029-017-0040-9
Subject(s) - lynch syndrome , medicine , dna mismatch repair , radiation therapy , biliary tract , dna repair , oncology , cancer , dna , genetics , colorectal cancer , biology
Patients with Lynch syndrome (LS) have a significantly elevated lifetime risk of developing biliary tract cancers (BTCs) compared to the general population. However, few studies have characterized the clinical characteristics, genetic features, or long-term outcomes of mismatch-repair deficient (dMMR) cholangiocarcinomas associated with LS.