Hepatitis B Virus-Associated Hepatocellular Carcinoma from India: Role of Viral Genotype and Mutations in CTNNB1 (Beta-Catenin) and TP53 Genes | Zendy

Perumal Vivekanandan | Zendy; Michael Torbenson | Zendy; Banumathi Ramakrishna | Zendy

Open Access

Hepatitis B Virus-Associated Hepatocellular Carcinoma from India: Role of Viral Genotype and Mutations in CTNNB1 (Beta-Catenin) and TP53 Genes

Author(s) -

Perumal Vivekanandan,

Michael Torbenson,

Banumathi Ramakrishna

Publication year - 2010

Publication title -

journal of gastrointestinal cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.473

H-Index - 47

eISSN - 1941-6628

pISSN - 1941-6636

DOI - 10.1007/s12029-010-9222-4

Subject(s) - genotype , hepatocellular carcinoma , hepatitis b virus , virology , genotyping , exon , biology , gene , hepatitis b , mutation , medicine , virus , cancer research , genetics

Chronic hepatitis B virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in India. Studies from other countries have linked HBV genotype C to a higher risk for HCC. This study was carried out to determine the association between genotype and HCC and also the frequency of mutations in CTNNB1 (beta-catenin) and TP53 genes in HBV-related HCC.

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