Open AccessHepatitis B Virus-Associated Hepatocellular Carcinoma from India: Role of Viral Genotype and Mutations in CTNNB1 (Beta-Catenin) and TP53 Genes
Author(s) -
Perumal Vivekanandan,
Michael Torbenson,
B. S. Ramakrishna
Publication year - 2010
Publication title -
journal of gastrointestinal cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.473
H-Index - 47
eISSN - 1941-6628
pISSN - 1941-6636
DOI - 10.1007/s12029-010-9222-4
Subject(s) - genotype , hepatocellular carcinoma , hepatitis b virus , virology , genotyping , exon , biology , gene , hepatitis b , mutation , medicine , virus , cancer research , genetics
Chronic hepatitis B virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in India. Studies from other countries have linked HBV genotype C to a higher risk for HCC. This study was carried out to determine the association between genotype and HCC and also the frequency of mutations in CTNNB1 (beta-catenin) and TP53 genes in HBV-related HCC.