Open AccessExploratory Assessment of the Relationship Between Hemoglobin Volume Phase Index, Magnetic Resonance Imaging, and Functional Outcome in Neonates with Hypoxic–Ischemic Encephalopathy
Author(s) -
An N. Massaro,
Jennifer K. Lee,
Gilbert Vézina,
Penny Glass,
A O'Kane,
Ruoying Li,
Taeun Chang,
Kenneth Martin Brady,
Rathinaswamy B. Govindan
Publication year - 2020
Publication title -
neurocritical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 74
eISSN - 1556-0961
pISSN - 1541-6933
DOI - 10.1007/s12028-020-01150-8
Subject(s) - medicine , magnetic resonance imaging , neurology , hypoxic ischemic encephalopathy , encephalopathy , cardiology , radiology , psychiatry
Near-infrared spectroscopy (NIRS)-based measures of cerebral autoregulation (CAR) can potentially identify neonates with hypoxic-ischemic encephalopathy (HIE) who are at greatest risk of irreversible brain injury. However, modest predictive abilities have precluded previously described metrics from entering clinical care. We previously validated a novel autoregulation metric in a piglet model of induced hypotension called the hemoglobin volume phase index (HVP). The objective of this study was to evaluate the clinical ability of the HVP to predict adverse outcomes neonates with HIE.