Open AccessInflammasome Caspase-1 Activity is Elevated in Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage and Predicts Functional Outcome
Author(s) -
Yonatan Hirsch,
Joseph R Geraghty,
Eitan Katz,
Fernando D. Testai
Publication year - 2020
Publication title -
neurocritical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 74
eISSN - 1556-0961
pISSN - 1541-6933
DOI - 10.1007/s12028-020-01113-z
Subject(s) - medicine , subarachnoid hemorrhage , glasgow outcome scale , cerebrospinal fluid , inflammasome , biomarker , lumbar puncture , neurology , receiver operating characteristic , glasgow coma scale , area under the curve , gastroenterology , anesthesia , inflammation , biochemistry , chemistry , psychiatry
Subarachnoid hemorrhage (SAH) is a devastating neurological injury, further complicated by few available methods to objectively predict outcomes. With the recent shift in focus to neuroinflammation as a potential cause of adverse outcomes following SAH, we investigated the inflammasome-derived enzyme, caspase-1, as a potential biomarker for poor functional outcome.