Open AccessGenetic Variability and Trajectories of DNA Methylation May Support a Role for HAMP in Patient Outcomes After Aneurysmal Subarachnoid Hemorrhage
Author(s) -
Lacey W. Heinsberg,
Annie I. Arockiaraj,
Elizabeth Crago,
Dianxu Ren,
John R. Shaffer,
Paula R. Sherwood,
Susan M. Sereika,
Daniel E. Weeks,
Yvette P. Conley
Publication year - 2019
Publication title -
neurocritical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 74
eISSN - 1556-0961
pISSN - 1541-6933
DOI - 10.1007/s12028-019-00787-4
Subject(s) - medicine , subarachnoid hemorrhage , dna methylation , glasgow outcome scale , methylation , confounding , modified rankin scale , genotype , bioinformatics , oncology , ischemia , gene , glasgow coma scale , genetics , psychiatry , ischemic stroke , biology , gene expression
Preclinical evidence suggests that iron homeostasis is an important biological mechanism following aneurysmal subarachnoid hemorrhage (aSAH); however, this concept is underexplored in humans. This study examined the relationship between patient outcomes following aSAH and genetic variants and DNA methylation in the hepcidin gene (HAMP), a key regulator of iron homeostasis.