Open AccessBiospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations
Author(s) -
Sherry Chou,
R. Loch Macdonald,
Emanuela Keller
Publication year - 2019
Publication title -
neurocritical care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 74
eISSN - 1556-0961
pISSN - 1541-6933
DOI - 10.1007/s12028-019-00725-4
Subject(s) - medicine , biomarker , systematic review , biomarker discovery , medline , molecular biomarkers , meta analysis , bioinformatics , medical physics , intensive care medicine , pathology , proteomics , oncology , biochemistry , chemistry , biology , political science , law , gene
Development of clinical biomarkers to guide therapy is an important unmet need in aneurysmal subarachnoid hemorrhage (SAH). A wide spectrum of plausible biomarkers has been reported for SAH, but none have been validated due to significant variabilities in study design, methodology, laboratory techniques, and outcome endpoints.