Open AccessImpact of adrenomedullin blockage on lipid metabolism in female mice exposed to high-fat diet
Author(s) -
Yuanlin Dong,
Nicola van der Walt,
Kathleen A. Pennington,
Chandra Yallampalli
Publication year - 2019
Publication title -
endocrine
Language(s) - English
Resource type - Journals
eISSN - 1559-0100
pISSN - 1355-008X
DOI - 10.1007/s12020-019-01927-8
Subject(s) - medicine , endocrinology , lipolysis , adrenomedullin , glucose homeostasis , adipose tissue , basal (medicine) , type 2 diabetes , insulin , white adipose tissue , carbohydrate metabolism , insulin resistance , diabetes mellitus , receptor
Adrenomedullin (ADM) levels are elevated in gestational and type 2 diabetic patients. ADM also stimulates lipolysis in vitro. Disturbed lipid metabolism has been implicated in the pathogenesis of diabetes. Here, we explore whether blockade of ADM is beneficial for metabolic homeostasis in a diabetic mouse model.