Open AccessThyroid hormone acting via TRβ induces expression of browning genes in mouse bone marrow adipose tissue
Author(s) -
Richard C Lindsey,
Subburaman Mohan
Publication year - 2017
Publication title -
endocrine
Language(s) - English
Resource type - Journals
eISSN - 1559-0100
pISSN - 1355-008X
DOI - 10.1007/s12020-017-1265-x
Subject(s) - endocrinology , medicine , bone marrow , thyroid , adipogenesis , stromal cell , adipose tissue , hormone , mesenchymal stem cell , adipocyte , thyroid hormone receptor , biology , pathology
Mutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent with the well-established effects of thyroid hormone on energy and fat metabolism. Since bone marrow mesenchymal stromal cells differentiate into both adipocytes and osteoblasts and a relationship between bone marrow adipogenesis and osteogenesis has been predicted, we hypothesized thyroid hormone deficiency during the postnatal growth period increases marrow adiposity in mice.