Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages | Zendy

Mohamed Abumaree | Zendy; Mohammed Al Jumah | Zendy; Bill Kalionis | Zendy; Dunia Jawdat | Zendy; Abdulaziz Al Khaldi | Zendy; Fawaz Abomaray | Zendy; Abulhamed Fatani | Zendy; Larry Chamley | Zendy; B. A. Knawy | Zendy

Open Access

Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages

Author(s) -

Mohamed Abumaree,

Mohammed Al Jumah,

Bill Kalionis,

Dunia Jawdat,

Abdulaziz Al Khaldi,

Fawaz Abomaray,

Abulhamed Fatani,

Larry Chamley,

B. A. Knawy

Publication year - 2013

Publication title -

stem cell reviews and reports

Language(s) - English

Resource type - Journals

eISSN - 1558-6804

pISSN - 1550-8943

DOI - 10.1007/s12015-013-9455-2

Subject(s) - cd86 , microbiology and biotechnology , biology , cd80 , macrophage , cellular differentiation , mesenchymal stem cell , cd40 , cd14 , immune system , immunology , t cell , cytotoxic t cell , in vitro , biochemistry , gene

Mesenchymal stem cells (MSCs) have a therapeutic potential in tissue repair because of capacity for multipotent differentiation and their ability to modulate the immune response. In this study, we examined the ability of human placental MSCs (pMSCs) to modify the differentiation of human monocytes into macrophages and assessed the influence of pMSCs on important macrophage functions.

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