Open AccessLongitudinal Growth and pQCT Measures in Hutterite Children and Grandchildren Are Associated With Prevalence of Hip or Knee Replacement Resulting From Osteoarthritis in Parents and Grandparents
Author(s) -
Lee A. Weidauer,
Tianna Beare,
Teresa L. Binkley,
Maggie Minett,
Bonny Specker
Publication year - 2018
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999.0000000000000197
Subject(s) - medicine , anthropometry , grandparent , osteoarthritis , confidence interval , bone mineral , quantitative computed tomography , longitudinal study , body mass index , osteoporosis , pathology , psychology , developmental psychology , alternative medicine
Osteoarthritis (OA) is one of the leading causes of disability in the world. Several genes are associated with the development of OA, and previous studies have shown adult children of individuals with OA have higher areal bone mineral density (BMD). Because childhood is an important period of growth and bone development, and body composition is known to be associated with BMD, we speculated that there may be differences in growth and bone measures among young children with a genetic predisposition to OA.