Open AccessIs Treatment With Dithiothreitol More Effective Than Sonication for the Diagnosis of Prosthetic Joint Infection?
Author(s) -
Andrea Sambri,
Matteo Cadossi,
Sandro Giannini,
Giovanni Pignatti,
Maurilio Marcacci,
Maria Pia Neri,
Alessandra Maso,
Elisa Storni,
Simonetta Gamberini,
Susanldi,
Arianna Torri,
Silvia Zannoli,
Martina Tassinari,
Manuela Fantini,
Giuseppe Bianchi,
Davide María Donati,
Vittorio Sambri
Publication year - 2018
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999.0000000000000060
Subject(s) - sonication , medicine , dithiothreitol , surgery , arthroplasty , prosthesis , radiology , biochemistry , chemistry , enzyme
Prosthetic joint infection (PJI) is among the most-severe complications of a total joint arthroplasty. Identification of the causal organism is of paramount importance for successful treatment, and sonication of implants may aid in this identification. Dithiothreitol (DTT) treatment has been proposed as an alternative to sonication to improve diagnosis, reduce costs, and improve reliability of the procedure, but its efficacy remains poorly characterized.