Open AccessChlorhexidine Antiseptic Irrigation Eradicates Staphylococcus epidermidis From Biofilm: An In Vitro Study
Author(s) -
Kenneth A. Schmidt,
Chris Estes,
A. C. McLaren,
Mark J. Spangehl
Publication year - 2018
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999.0000000000000052
Subject(s) - medicine , antiseptic , chlorhexidine , staphylococcus epidermidis , biofilm , microbiology and biotechnology , dentistry , staphylococcus aureus , bacteria , biology , pathology , genetics
Antiseptic and antibacterial solutions used for intraoperative irrigation are intended to kill bacteria and thereby decrease the incidence of surgical site infections. It is unknown if the concentrations and exposure times of irrigation solutions commonly used for prophylaxis in clean cases (povidone-iodine 0.35% for 3 minutes) are effective against bacteria in biofilm that are present in implant infections. Currently, povidone-iodine (0.35%), chlorhexidine (0.05%), sodium hypochlorite (0.125%), and triple antibacterial solution are all being used off-label for wound irrigation after surgical débridement for orthopaedic infections.