Open AccessThe Alpha-defensin Test for Periprosthetic Joint Infections Is Not Affected by Prior Antibiotic Administration
Author(s) -
Alisina Shahi,
Javad Parvızı,
Gregory S. Kazarian,
Carlos A. Higuera,
Salvatore J. Frangiamore,
Joshua S. Bingham,
C.P. Beauchamp,
Craig Della Valle,
Carl Deirmengian
Publication year - 2016
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999-016-4726-2
Subject(s) - medicine , antibiotics , periprosthetic , abx test , synovial fluid , gastroenterology , surgery , arthroplasty , pathology , microbiology and biotechnology , osteoarthritis , statistics , alternative medicine , mathematics , biology
Previous studies have demonstrated that the administration of antibiotics to patients before performing diagnostic testing for periprosthetic joint infection (PJI) can interfere with the accuracy of test results. Although a single-institution study has suggested that alpha-defensin maintains its concentration and sensitivity even after antibiotic treatment, this has not yet been demonstrated in a larger multiinstitutional study.