Open AccessSynovial Cytokines and the MSIS Criteria Are Not Useful for Determining Infection Resolution After Periprosthetic Joint Infection Explantation
Author(s) -
Salvatore J. Frangiamore,
Marcelo Siqueira,
Anas Saleh,
Thomas M. Daly,
Carlos A. Higuera,
Wael K. Barsoum
Publication year - 2016
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999-016-4710-x
Subject(s) - medicine , periprosthetic , synovial fluid , stage (stratigraphy) , arthroplasty , aseptic processing , cytokine , surgery , prospective cohort study , pathology , osteoarthritis , paleontology , alternative medicine , biology
Diagnosing periprosthetic joint infection (PJI) requires a combination of clinical and laboratory parameters, which may be expensive and difficult to interpret. Synovial fluid cytokines have been shown to accurately differentiate septic from aseptic failed total knee (TKA) and hip (THA) arthroplasties. However, after first-stage explantation, there is still no reliable test to rule out PJI before a second-stage reimplantation procedure.