Open AccessPorphyrin-adsorbed Allograft Bone: A Photoactive, Antibiofilm Surface
Author(s) -
Sana Dastgheyb,
Cyrus B. Toorkey,
Irving M. Shapiro,
Noreen J. Hickok
Publication year - 2015
Publication title -
clinical orthopaedics and related research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999-015-4299-5
Subject(s) - medicine , porphyrin , adsorption , dentistry , photochemistry , surgery , organic chemistry , chemistry
Allograft bone is commonly used to augment bone stock. Unfortunately, allograft is prone to bacterial contamination and current antimicrobial therapies are inadequate. Photoactivated porphyrins combat bacterial growth by production of reactive oxygen species (ROS); however, to our knowledge, they have not been tested in the setting of allograft bone.