Open AccessCan Regional Anesthesia and Analgesia Prolong Cancer Survival After Orthopaedic Oncologic Surgery?
Author(s) -
Juan P. Cata,
Mike Hernandez,
Valerae O. Lewis,
Andrea Kurz
Publication year - 2014
Publication title -
clinical orthopaedics and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.178
H-Index - 204
eISSN - 1528-1132
pISSN - 0009-921X
DOI - 10.1007/s11999-013-3306-y
Subject(s) - medicine , perioperative , cancer , surgical stress , breast cancer , mastectomy , surgery , anesthetic , disease , anesthesiology , anesthesia
The perioperative period of major oncologic surgery is characterized by immunosuppression, angiogenesis, and an increased load of circulating malignant cells. It is a window period in which cancer cells may seed, invade, and proliferate. Thus, it has been hypothesized that the use of regional anesthesia with the goal of reducing surgical stress and opioid and volatile anesthetic consumption would avoid perioperative immune suppression and angiogenesis and ultimately cancer recurrence.