Open AccessGenetic Gastric Cancer Risk Syndromes
Author(s) -
Benjamin A. Lerner,
Xavier Llor
Publication year - 2020
Publication title -
current treatment options in gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1534-309X
pISSN - 1092-8472
DOI - 10.1007/s11938-020-00312-z
Subject(s) - medicine , cancer , familial adenomatous polyposis , penetrance , cdh1 , lynch syndrome , genetic testing , colorectal cancer , cancer syndrome , gastroenterology , oncology , germline mutation , mutation , genetics , gene , dna mismatch repair , biology , phenotype , cadherin , cell
Gastric cancer is a leading cause of cancer death in the world. Between 1% and 3% of cases are associated with specific genetic cancer risk syndromes. The purpose of this article is to review the latest insights, as well as gaps in knowledge, regarding some of the most common hereditary gastric cancer syndromes: hereditary diffuse gastric cancer (HDGC), gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS), Lynch syndrome, the adenomatous polyposis syndromes, and the hamartomatous polyposis syndromes.