Open AccessGenetic testing for hereditary gastrointestinal cancer syndromes: Interpreting results in today's practice
Author(s) -
Jacquelyn Powers,
Jessica Ebrahimzadeh,
Bryson W. Katona
Publication year - 2019
Publication title -
current treatment options in gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1534-309X
pISSN - 1092-8472
DOI - 10.1007/s11938-019-00253-2
Subject(s) - genetic testing , medicine , popularity , genetic predisposition , cancer , genetic counseling , personalized medicine , lynch syndrome , bioinformatics , intensive care medicine , genetics , colorectal cancer , disease , pathology , biology , dna mismatch repair , psychology , social psychology
Advances in genomics have led to the discovery of multiple predisposition genes linked to increased risk for gastrointestinal (GI) cancer. The goal of this review is to assist physicians and allied health care professionals in understanding the current paradigm shift in clinical genetic testing for hereditary GI cancer predisposition syndromes; with a focus on multigene panel testing (MGPT) and test results interpretation. Additionally, this review introduces direct-to-consumer and at-home genetic testing. Both delivery models are increasing in popularity and clinicians will be expected to address results from patients who utilize these approaches.