Open AccessEpigenetic Mechanisms of Pancreatobiliary Fibrosis
Author(s) -
Sayed Obaidullah Aseem,
Robert C. Huebert
Publication year - 2019
Publication title -
current treatment options in gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1534-309X
pISSN - 1092-8472
DOI - 10.1007/s11938-019-00239-0
Subject(s) - epigenetics , dna methylation , crosstalk , medicine , chromatin , histone , bioinformatics , cancer research , pancreatic cancer , chromatin remodeling , epigenesis , fibrosis , biology , cancer , pathology , gene , genetics , gene expression , physics , optics
The goal of this manuscript is to review the current literature related to fibrogenesis in the pancreatobiliary system and how this process contributes to pancreatic and biliary diseases. In particular, we seek to define the current state of knowledge regarding the epigenetic mechanisms that govern and regulate tissue fibrosis in these organs. A better understanding of these underlying molecular events will set the stage for future epigenetic therapeutics.