Open AccessDo Interactions of Vitamin D3 and BMP Signaling Hold Implications in the Pathogenesis of Fibrodysplasia Ossificans Progressiva?
Author(s) -
Jessica L. Pierce,
Daniel S. Perrien
Publication year - 2021
Publication title -
current osteoporosis reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.472
H-Index - 57
eISSN - 1544-2241
pISSN - 1544-1873
DOI - 10.1007/s11914-021-00673-z
Subject(s) - fibrodysplasia ossificans progressiva , endochondral ossification , medicine , vitamin d and neurology , chondrogenesis , myositis ossificans , vitamin , endocrinology , heterotopic ossification , bioinformatics , pathology , cartilage , biology , surgery , anatomy
Fibrodysplasia ossificans progressiva (FOP) is a debilitating rare disease known for episodic endochondral heterotopic ossification (HO) caused by gain-of-function mutations in ACVR1/ALK2. However, disease severity varies among patients with identical mutations suggesting disease-modifying factors, including diet, may have therapeutic implications. The roles of vitamin D 3 in calcium metabolism and chondrogenesis are known, but its effects on BMP signaling and chondrogenesis are less studied. This review attempts to assess the possibility of vitamin D's effects in FOP by exploring relevant intersections of VD 3 with mechanisms of FOP flares.