Open AccessFailures of Endochondral Ossification in the Mucopolysaccharidoses
Author(s) -
Zhirui Jiang,
Sharon Byers,
Margret L. Casal,
Lachlan J. Smith
Publication year - 2020
Publication title -
current osteoporosis reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.472
H-Index - 57
eISSN - 1544-2241
pISSN - 1544-1873
DOI - 10.1007/s11914-020-00626-y
Subject(s) - endochondral ossification , cartilage , chondrocyte , short stature , ossification , medicine , stem cell , biology , microbiology and biotechnology , endocrinology , anatomy
The mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders characterized by abnormal accumulation of glycosaminoglycans (GAGs) in cells and tissues. MPS patients frequently exhibit failures of endochondral ossification during postnatal growth leading to skeletal deformity and short stature. In this review, we outline the current understanding of the cellular and molecular mechanisms underlying failures of endochondral ossification in MPS and discuss associated treatment challenges and opportunities.