Open AccessInflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification
Author(s) -
Koji Matsuo,
Robert Dalton Chavez,
Emilie Barruet,
Edward C. Hsiao
Publication year - 2019
Publication title -
current osteoporosis reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.472
H-Index - 57
eISSN - 1544-2241
pISSN - 1544-1873
DOI - 10.1007/s11914-019-00541-x
Subject(s) - fibrodysplasia ossificans progressiva , heterotopic ossification , inflammation , ossification , immune system , medicine , immunology , signal transduction , bioinformatics , biology , microbiology and biotechnology , anatomy
Heterotopic ossification (HO) is associated with inflammation. The goal of this review is to examine recent findings on the roles of inflammation and the immune system in HO. We examine how inflammation changes in fibrodysplasia ossificans progressiva, in traumatic HO, and in other clinical conditions of HO. We also discuss how inflammation may be a target for treating HO.