Open AccessInvestigating Osteocytic Perilacunar/Canalicular Remodeling
Author(s) -
Cristal S. Yee,
Charles A. Schurman,
Carter R. White,
Tamara Alliston
Publication year - 2019
Publication title -
current osteoporosis reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.472
H-Index - 57
eISSN - 1544-2241
pISSN - 1544-1873
DOI - 10.1007/s11914-019-00514-0
Subject(s) - osteocyte , extracellular matrix , neuroscience , skeleton (computer programming) , biology , disease , homeostasis , in vivo , bone matrix , microbiology and biotechnology , bone remodeling , bioinformatics , medicine , pathology , computational biology , in vitro , anatomy , endocrinology , osteoblast , genetics , cartilage
In perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintaining homeostasis of the skeleton. The goal of this review is to examine the motivations and critical considerations for the analysis of PLR, in both in vitro and in vivo systems.