Open AccessNuclear Fibroblast Growth Factor Receptor Signaling in Skeletal Development and Disease
Author(s) -
Creighton T. Tuzon,
Diana Rigueur,
Amy E. Merrill
Publication year - 2019
Publication title -
current osteoporosis reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.472
H-Index - 57
eISSN - 1544-2241
pISSN - 1544-1873
DOI - 10.1007/s11914-019-00512-2
Subject(s) - fibroblast growth factor receptor , biology , microbiology and biotechnology , importin , transcription factor , fibroblast growth factor , nuclear transport , nuclear receptor , cell nucleus , cancer research , genetics , receptor , nucleus , gene
Fibroblast growth factor receptor (FGFR) signaling regulates proliferation and differentiation during development and homeostasis. While membrane-bound FGFRs play a central role in these processes, the function of nuclear FGFRs is also critical. Here, we highlight mechanisms for nuclear FGFR translocation and the effects of nuclear FGFRs on skeletal development and disease.