Open AccessTyrosine Kinase Inhibition: a New Perspective in the Fight against HIV
Author(s) -
Sara Rodríguez-Mora,
Adam M. Spivak,
Matthew A. Szaniawski,
María Rosa López-Huertas,
José Alcamı́,
Vicente Planelles,
Mayte Coiras
Publication year - 2019
Publication title -
current hiv/aids reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.135
H-Index - 56
eISSN - 1548-3576
pISSN - 1548-3568
DOI - 10.1007/s11904-019-00462-5
Subject(s) - dasatinib , samhd1 , cart , persistence (discontinuity) , tyrosine kinase , mechanism (biology) , virology , human immunodeficiency virus (hiv) , biology , immunology , microbiology and biotechnology , signal transduction , reverse transcriptase , genetics , mechanical engineering , rna , philosophy , geotechnical engineering , epistemology , gene , engineering
HIV-1 infection is incurable due to the existence of latent reservoirs that persist in the face of cART. In this review, we describe the existence of multiple HIV-1 reservoirs, the mechanisms that support their persistence, and the potential use of tyrosine kinase inhibitors (TKIs) to block several pathogenic processes secondary to HIV-1 infection.