Open AccessSkeletal maturity of children with multiple osteochondromas: Is diminished stature due to a systemic influence?
Author(s) -
Heleen Staal,
Annemarie L. Goud,
Henk-Jan van der Woude,
M.A. Witlox,
S.J. Ham,
Simon G. F. Robben,
Marjolein Dremmen,
Lodewijk W. van Rhijn
Publication year - 2015
Publication title -
journal of children's orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.638
H-Index - 36
eISSN - 1863-2548
pISSN - 1863-2521
DOI - 10.1007/s11832-015-0680-x
Subject(s) - short stature , maturity (psychological) , developmental psychology , psychology , medicine , pediatrics
Multiple ostechondromas (MO) is an autosomal dominant inherited disease caused by mutated exostosin genes. It mostly affects the long bones and can lead to growth disturbances, especially disproportionate short stature. Both the local effect on growth plates and the systemic influence of the gene disorder on growth mechanisms might explain the diminished stature.