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Efficient intraliposomal entrapment of hydrophilic platinum oligonuclear complexes
Author(s) -
Ogawa Yoshikatsu,
Yamazaki Yoshimitsu,
Kodaka Masato,
Okuno Hiroaki
Publication year - 1998
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/s11746-998-0129-1
Subject(s) - chemistry , platinum , liposome , uridine , nuclear chemistry , biochemistry , rna , catalysis , gene
A simple method for intraliposomal entrapment of platinum complexes is presented, where hydrophilic platinum oligonuclear complexes, 1‐methyluracil green (MeUG), uridine green (UdG) and uridine blue (UdB), are included inside liposomes and allowed to react with bilayer lipids. The liposomes prepared in this method exhibit higher entrapment efficiency and higher distribution to organs (liver, kidney, spleen, lung) and blood (but not B16 cancer cells) than those prepared from mononuclear Pt complexes [ cis ‐diamminedichloroplatinum, cis ‐diammine‐1,1′‐dicarboxylatocyclobutaneplatinum, and cis ‐dichloro‐ cis ‐dihydroxy‐ trans ‐bis(isopropylamine)platinum)].