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High‐purity γ‐linolenic acid from borage oil fatty acids
Author(s) -
Ju YiHsu,
Chen TorChern
Publication year - 2002
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/s11746-002-0430-9
Subject(s) - fatty acid , chemistry , yield (engineering) , crystallization , lipase , solvent , oleic acid , alcohol , catalysis , ethanol , linolenic acid , butanol , gamma linolenic acid , organic chemistry , chromatography , biochemistry , polyunsaturated fatty acid , enzyme , materials science , linoleic acid , metallurgy
High‐purity γ‐linolenic acid (GLA) was obtained by employing a modified low‐temperature solvent crystallization process, followed by a lipase‐catalyzed esterification, to borage oil fatty acid. By applying a two‐stage solvent crystallization process to the borage oil fatty acid, GLA content was increased from 23.4 to 92.1% with a yield of 89.3%. After the esterification of GLA‐rich fatty acid with butanol catalyzed by Lipozyme IM‐60, GLA content in the fatty acid was further raised from 92.1 to 99.1%. The overall yield of the combined process was 72.8%. The effects of operation parameters on the Lipozyme IM‐60 catalyzed esterification between fatty acid and alcohol were systematically investigated.