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Free radical scavenging capacity as related to antioxidant activity and ginsenoside composition of Asian and North American ginseng extracts
Author(s) -
Hu Chun,
Kitts David D.
Publication year - 2001
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/s11746-001-0253-8
Subject(s) - ginseng , chemistry , ginsenoside , american ginseng , antioxidant , lipid peroxidation , araliaceae , traditional medicine , radical , food science , chromatography , biochemistry , medicine , alternative medicine , pathology
Different Panax species derived from Asia ( Panax ginseng C.A. Meyer) and North America ( Panax quinquefolium L.) were extracted by methanol and evaluated for relative ginsenoside composition and antioxidant activities. Ginseng root contained a greater proportion of total ginsenoside compared to ginseng hair analyzed by high‐performance liquid chromatography. North American ginseng root was characterized with undetectable ginsenoside Rf and greater Rb 1 /Rb 2 than Asian ginseng root. Panax quinquefolium exhibited a relatively higher ( P <0.05) affinity to scavenge free radical than panax ginseng using the 2,2‐azobis (3‐ethylbenzothine‐6‐thine‐6‐surfonic acid) radical model. In a bilayer lamella suspension oxidation model induced by peroxyl radicals, ginseng samples exhibited notable antioxidant activity. Specifically, however, the P. quinquefolium extracts delayed lipid peroxidation longer ( P <0.05) than the P. ginseng extracts. Ginseng extracts from both Panax species protected human low‐density lipoprotein against cupric ion‐mediated oxidation. Similar protection was observed against peroxyl radical‐induced supercoiled DNA breakage. A pure ginsenoside standard (e.g., Rb 1 ) produced similar results. The antioxidant activities of different ginseng species and specific plant parts include free radical scavenging and may be related to ginsenoside Rb 1 /Rb 2 content.