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Selection of alcohols through Plackett‐Burman design in lipase‐catalyzed synthesis of anthranilic acid esters
Author(s) -
Babu C. V. Suresh,
Divakar S.
Publication year - 2001
Publication title -
journal of the american oil chemists' society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 117
eISSN - 1558-9331
pISSN - 0003-021X
DOI - 10.1007/s11746-001-0218-y
Subject(s) - anthranilic acid , plackett–burman design , lipase , methanol , chemistry , yield (engineering) , catalysis , organic chemistry , alcohol , enzyme , materials science , fermentation , metallurgy
Lipase‐catalyzed synthesis of esters of anthranilic acid was attempted by employing alcohols of carbon chainlength C 1 –C 18 using Plackett‐Burman experimental design. Of the alcohols employed, methanol, decanol, cetyl alcohol, and stearyl alcohols showed 99.9% significance. Esterification of anthranilic acid with methanol gave the highest yield at 45.6%. This study allows the selection of better alcohols for esterification of anthranilic acid.