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Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro
Author(s) -
Bretillon L.,
Chardigny J. M.,
Grégoire S.,
Berdeaux O.,
Sébédio J. L.
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-999-0446-9
Subject(s) - stearic acid , clinical chemistry , chemistry , microsome , conjugated linoleic acid , linoleic acid , lipidology , in vitro , conjugated system , microsoma , chromatography , biochemistry , organic chemistry , fatty acid , polymer
The influence of individual conjugated linoleic acid (CLA) isomers on the Δ6 desaturation of linoleic and α‐linolenic acids and on the Δ9 desaturation of stearic acid was investigated in vitro , using rat liver microsomes. The Δ6 desaturation of 18∶2n−6 was decreased from 23 to 38% when the ratio of 9 cis ,11 trans ‐18∶2 to 18∶2n−6 increased from 0.5 to 2. The compound 10 trans ,12 cis ‐18∶2 exhibited a similar effect only at the highest concentration. The Δ6 desaturation of α‐linolenic acid was slightly affected by the presence of CLA isomers. The sole isomer to induce an inhibitory effect on the Δ9 desaturation of stearic acid was 10 trans ,12 cis ‐18∶2.