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Lymphatic absorption of phytosterol oxides in rats
Author(s) -
Grandgirard André,
Sergiel JeanPierre,
Nour Mohammed,
DemaisonMeloche Joelle,
Gihiès Christian
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-999-0399-z
Subject(s) - campesterol , phytosterol , chemistry , absorption (acoustics) , clinical chemistry , alicyclic compound , lipidology , lymphatic system , organic chemistry , biochemistry , medicine , materials science , cholesterol , sterol , pathology , composite material
Two of the main classes of oxyphytosterols (7‐keto and epoxides) were synthesized from sitosterol and campesterol and given to mesenteric duct‐cannulated adult male rats. Lymph was collected during 24 h and was analyzed for oxysterols. The results showed that the lymphatic recovery of the phytosterol oxides was low: 4.7% of the given dose for epoxy derivatives and 1.5% for 7‐keto compounds. The campesterol oxides presented a better absorption than the sitosterol oxides. During the process of absorption’ the epoxyphytostanols were also partly transformed in campestanetriol and stigmastanetriol.