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Synthetic routes to lipidic diamines and amino alcohols: A class of potential antiinflammatory agents
Author(s) -
Kokotos George,
ConstantinouKokotou Violetta,
Noula Caterina,
HadjipavlouLitina Dimitra
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-999-0368-6
Subject(s) - amino acid , lipidology , chemistry , organic chemistry , in vivo , diamine , combinatorial chemistry , clinical chemistry , biochemistry , biology , microbiology and biotechnology
Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2‐amino alcohols and 1,3‐diamines can be synthesized starting from synthetic lipidic α‐amino acids. Alternatively, commercially available lipidic 1,2‐diols may be used as starting material for the synthesis of 2‐amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results.