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Evidence that the trans ‐10, cis ‐12 isomer of conjugated linoleic acid induces body composition changes in mice
Author(s) -
Park Yeonhwa,
Storkson Jayne M.,
Albright Karen J.,
Liu Wei,
Pariza Michael W.
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-999-0358-8
Subject(s) - conjugated linoleic acid , chemistry , cis–trans isomerism , clinical chemistry , composition (language) , glycerol , lipidology , linoleic acid , biochemistry , stereochemistry , fatty acid , philosophy , linguistics
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis ‐9, trans ‐11 CLA isomer or the trans ‐10, cis ‐12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans ‐10, cis ‐12 CLA isomer. In cultured 3T3‐L1 adipocytes, the trans ‐10, cis ‐12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis ‐9, trans ‐11 and trans ‐9, trans ‐11 CLA isomers did not affect these biochemical activities. We conclude that CLA‐associated body composition change results from feeding the trans ‐10, cis ‐12 isomer.