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Recent advances in brain cholesterol dynamics: Transport, domains, and Alzheimer's disease
Author(s) -
Wood W. Gibson,
Schroeder Friedhelm,
Avdulov Nicolai A.,
Chochina Svetlana V.,
Igbavboa Urule
Publication year - 1999
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-999-0357-9
Subject(s) - cholesterol , lipidology , disease , neuroscience , clinical chemistry , dynamics (music) , alzheimer's disease , biology , medicine , biochemistry , psychology , pedagogy
Abstract Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.