Premium
Facile and general method for preparation of ( E )‐4‐hydroxy‐2‐alkenals
Author(s) -
Sugamoto Kazuhiro,
Matsushita Yohichi,
Matsui Takanao
Publication year - 1997
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-997-0116-y
Subject(s) - triethylsilane , porphyrin , chemistry , lipidology , catalysis , cobalt , clinical chemistry , organic chemistry , medicinal chemistry , biochemistry
A facile one‐pot synthesis of ( E )‐4‐hydroxy‐2‐alkenals such as ( E )‐4‐hydroxy‐2‐nonenal, ( E )‐4‐hydroxy‐2‐heptenal, and ( E )‐4‐hydroxy‐2‐hexenal was achieved from the corresponding (2 E ,4 E )‐2,4‐alkadienals by reduction‐oxygenation with molecular oxygen and triethylsilane in the presence of cobalt(II) porphyrin as a catalyst followed by treatment with trimethylphosphite.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom