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Facile and general method for preparation of ( E )‐4‐hydroxy‐2‐alkenals
Author(s) -
Sugamoto Kazuhiro,
Matsushita Yohichi,
Matsui Takanao
Publication year - 1997
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-997-0116-y
Subject(s) - triethylsilane , porphyrin , chemistry , lipidology , catalysis , cobalt , clinical chemistry , organic chemistry , medicinal chemistry , biochemistry
A facile one‐pot synthesis of ( E )‐4‐hydroxy‐2‐alkenals such as ( E )‐4‐hydroxy‐2‐nonenal, ( E )‐4‐hydroxy‐2‐heptenal, and ( E )‐4‐hydroxy‐2‐hexenal was achieved from the corresponding (2 E ,4 E )‐2,4‐alkadienals by reduction‐oxygenation with molecular oxygen and triethylsilane in the presence of cobalt(II) porphyrin as a catalyst followed by treatment with trimethylphosphite.