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Lipid peroxidation during n−3 fatty acid and vitamin E supplementation in humans
Author(s) -
Allard Johane P.,
Kurian Regina,
Aghdassi Elaheh,
Muggli Reto,
Royall Dawna
Publication year - 1997
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-997-0068-2
Subject(s) - lipid peroxidation , vitamin e , chemistry , docosahexaenoic acid , malondialdehyde , antioxidant , polyunsaturated fatty acid , lipidology , phospholipid , food science , lipid peroxide , tocopheryl acetate , eicosapentaenoic acid , fatty acid , vitamin , medicine , biochemistry , membrane
The purpose of this study was to investigate in healthy humans the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake, alone or in combination with dL‐α‐tocopherol acetate (vitamin E) supplements on lipid peroxidation. Eightly men were randomly assigned in a double‐blind fashion to take daily for 6 wk either menhaden oil (6.26 g, n−3 fatty acids) or olive oil supplements with either vitamin E (900 IU) or its placebo. Antioxidant vitamins, phospholipid composition, malondialdehyde (MDA), and lipid peroxides were measured in the plasma at baseline and week 6. At the same time, breath alkane output was measured. Plasma α‐tocopherol concentration increased in those receiving vitamin E ( P <0.0001). In those supplemented with n−3 fatty acids, EPA and DHA increased in plasma phospholipids ( P <0.0001) and plasma MDA and lipid peroxides increased ( P <0.001 and P <0.05, respectively). Breath alkane output did not change significantly and vitamin E intake did not prevent the increase in lipid peroxidation during menhaden oil supplementation. The results demonstrate that supplementing the diet with n−3 fatty acids resulted in an increase in lipid peroxidation, as measured by plasma MDA release and lipid peroxide products, which was not suppressed by vitamin E supplementation.