Premium
Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids
Author(s) -
Street James C.,
Koutcher Jason A.
Publication year - 1997
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-997-0007-2
Subject(s) - phosphatidylethanolamine , phospholipid , phosphatidylcholine , phosphocholine , clinical chemistry , chemistry , lipidology , cyclophosphamide , chemotherapy , radiation therapy , liposome , tomotherapy , biochemistry , membrane , composition (language) , medicine , endocrinology , biology , linguistics , philosophy
Abstract Phospholipid extracts were made of a murine mammary adenocarcinoma implanted in the dorsum of the foot of C3H/He mice before and 96 h after 17 Gy irradiation or 150 mg/kg cyclophosphamide. Extracts of untreated tumors, which had grown for a further 96 h, were also studied. Although previous studies have shown significant changes in the precursors and catabolites of phosphatidylcholine and phosphatidylethanolamine following therapy, 31 P nuclear magnetic resonance analysis of extracts showed no changes in these membrane constituents and other observed phospholipid species. A significant decrease in 1‐alkyl‐2‐acyl‐ sn ‐glycero‐3‐phosphocholine, however, was observed 96 h following cyclophosphamide treatment.