Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids | Zendy

Street James C. | Zendy; Koutcher Jason A. | Zendy

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Effect of radiotherapy and chemotherapy on composition of tumor membrane phospholipids

Author(s) -

Street James C.,

Koutcher Jason A.

Publication year - 1997

Publication title -

lipids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.601

H-Index - 120

eISSN - 1558-9307

pISSN - 0024-4201

DOI - 10.1007/s11745-997-0007-2

Subject(s) - phosphatidylethanolamine , phospholipid , phosphatidylcholine , phosphocholine , clinical chemistry , chemistry , lipidology , cyclophosphamide , chemotherapy , radiation therapy , liposome , tomotherapy , biochemistry , membrane , composition (language) , medicine , endocrinology , biology , linguistics , philosophy

Phospholipid extracts were made of a murine mammary adenocarcinoma implanted in the dorsum of the foot of C3H/He mice before and 96 h after 17 Gy irradiation or 150 mg/kg cyclophosphamide. Extracts of untreated tumors, which had grown for a further 96 h, were also studied. Although previous studies have shown significant changes in the precursors and catabolites of phosphatidylcholine and phosphatidylethanolamine following therapy, 31 P nuclear magnetic resonance analysis of extracts showed no changes in these membrane constituents and other observed phospholipid species. A significant decrease in 1‐alkyl‐2‐acyl‐ sn ‐glycero‐3‐phosphocholine, however, was observed 96 h following cyclophosphamide treatment.

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