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Medium‐Chain Enriched Diacylglycerol (MCE‐DAG) Oil Decreases Body Fat Mass in Mice by Increasing Lipolysis and Thermogenesis in Adipose Tissue
Author(s) -
Kim Haeun,
Choe JeeHwan,
Choi Jong Hun,
Kim Hun Jung,
Park Soo Hyun,
Lee Moon Won,
Kim Wooki,
Go Gwangwoong
Publication year - 2017
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-017-4277-7
Subject(s) - adipose tissue , lipolysis , endocrinology , adipose triglyceride lipase , thermogenesis , canola , medicine , white adipose tissue , chemistry , triglyceride , lipidology , brown adipose tissue , clinical chemistry , biology , food science , cholesterol
Medium chain fatty acid (MCFA) escapes the formation of chylomicrons in the small intestine, resulting in energy expenditure through beta‐oxidation. Diacylglycerol (DAG) is susceptible to oxidation rather than being stored in the adipose tissue. This study was conducted to verify the effect of MCE‐DAG oil on body fat mass in vivo . Male C57BL/6 mice were randomly assigned to four groups ( n = 12) as follows: (1) normal diet (18% kcal from fat), (2) canola oil as a control (40% kcal from canola oil), (3) MCE‐DAG10 (10% kcal from MCE‐DAG + 30% kcal from canola oil), and (4) MCE‐DAG20 (20% kcal from MCE‐DAG + 20% kcal from canola oil). The body weight and fat mass of MCE‐DAG20 group mice were decreased relative to those of control mice ( P < 0.05 and P < 0.001, respectively). Serum triacylglycerol (TAG) was decreased in both MCE‐DAG10 and MCE‐DAG20 groups ( P < 0.01 and P < 0.05, respectively). Hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) were increased in the MCE‐DAG20 group relative to the control in white adipose tissue (WAT) ( P < 0.05). Uncoupling protein 1 (UCP1) was also increased in the MCE‐DAG20 group relative to the control in brown adipose tissue (BAT) ( P < 0.05). In summary, MCE‐DAG reduced body fat mass likely by stimulating lipolysis in WAT and thermogenesis in BAT.