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New Role of Hispidulin in Lipid Metabolism: PPARα Activator
Author(s) -
Wu Xinchi,
Xu Juan
Publication year - 2016
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-016-4200-7
Subject(s) - thymelaeaceae , dyslipidemia , chemistry , lipid metabolism , pharmacology , fenofibrate , agonist , biochemistry , biology , receptor , botany , endocrinology , diabetes mellitus
Hispidulin is a naturally occurring flavonoid isolated from a traditional Chinese medicinal herb, Saussurea involucrata . In this study, the regulating role of hispidulin on the mRNA expression level of enzymes involved in lipid metabolism was examined in vitro and in vivo . Moreover, the in vivo lipid‐modulating effect of hispidulin was compared with that of fenofibrate, a classical PPARα agonist. Our results in present study demonstrated that hispidulin can directly bind to and activate PPARα as an agonist and thus modulate the downstream lipid‐metabolizing genes. Moreover, hispidulin could attenuate dyslipidemia in high fat diet induced dyslipidemia rat model. Although further studies are needed, this study provided evidence for the potential use of hispidulin in dyslipidemia management.