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Enhanced Bioavailability of EPA From Emulsified Fish Oil Preparations Versus Capsular Triacylglycerol
Author(s) -
Raatz Susan K.,
Johnson LuAnn K.,
Bukowski Michael R.
Publication year - 2016
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-015-4100-2
Subject(s) - fish oil , bioavailability , food science , fatty acid , chemistry , phospholipid , triglyceride , lipidology , emulsion , chylomicron , clinical chemistry , docosahexaenoic acid , chromatography , polyunsaturated fatty acid , biochemistry , fish <actinopterygii> , biology , cholesterol , pharmacology , fishery , lipoprotein , very low density lipoprotein , membrane
For those individuals who are unable to consume adequate long chain omega‐3 fatty acids (LCn3) from dietary sources, fish oil supplementation is an attractive alternative Pre‐emulsified fish oil supplements, an alternative to capsular triacylglycerol, may enhance the uptake of LCn3 fatty acids it contains. A randomized, Latin‐square crossover design was used to compare the effects of four fish oil supplement preparations (Emulsions S, B and N) on phospholipid fatty acid (PLFA) concentrations in ten healthy volunteers compared to oil capsules over 48 h after a single dose and chylomicron fatty acid (CMFA) was evaluated over 8 h. Blood samples were collected at 0, 2, 4, 8, 24 and 48 h and fatty acid concentrations of PLFA and CMFA were determined by gas chromatography and the integrated area under the curve over 40 h ( i AUC 0–48 ) was determined. Emulsion S and Emulsion N promoted increased uptake of EPA into PLFA over 48 h when evaluating by i AUC 0–48 or individual time points of assessment. No differences were observed between supplements in the CMFA concentrations.