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Lysophospholipids from the Guangxi Sponge Spirastrella purpurea
Author(s) -
Lin Kun,
Yang Peng,
Yang Hui,
Liu AiHong,
Yao LiGong,
Guo YueWei,
Mao ShuiChun
Publication year - 2015
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-015-4028-6
Subject(s) - aspergillus fumigatus , sponge , stereochemistry , heteronuclear single quantum coherence spectroscopy , dept , chemistry , cryptococcus neoformans , candida glabrata , antifungal , microbiology and biotechnology , two dimensional nuclear magnetic resonance spectroscopy , biology , botany
Four known ( 1 – 4 ) and two new ( 5 and 6 ) lysophospholipids were isolated from the sponge Spirastrella purpurea from Weizhou Island, Guangxi Autonomous Region, China. The structures of the new compounds ( 5 and 6 ) were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR ( 1 H and 13 C NMR, 1 H– 1 H COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments. The known compounds ( 1 – 4 ) were identified by comparison of their spectroscopic data and specific optical rotation with those reported in the literature. The isolated compounds displayed various moderate in vitro antifungal activities against four fungi ( Cryptococcus neoformans , Candida glabrata , Trichophyton rubrum , and Aspergillus fumigatus ), whereas they displayed no neuroprotective activity against Aβ 25‐35 ‐induced SH‐SY5Y cell damage.