Premium
Fatty Acid Profile of Cardiac Muscle Phospholipid and Triacylglycerol in MDX Mice and C57BL/10ScSnJ Controls
Author(s) -
Tuazon Marc A.,
Henderson Gregory C.
Publication year - 2013
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-013-3811-5
Subject(s) - mdx mouse , skeletal muscle , duchenne muscular dystrophy , medicine , endocrinology , docosahexaenoic acid , cardiac muscle , muscular dystrophy , lipidology , context (archaeology) , phospholipid , biology , fatty acid , chemistry , clinical chemistry , biochemistry , dystrophin , polyunsaturated fatty acid , paleontology , membrane
The mdx mouse is a model for Duchenne muscular dystrophy (DMD), a debilitating disease affecting striated muscle. It is established that the fatty acid (FA) composition of skeletal muscle phospholipid (PL) is altered in mdx mice, but it is not known if cardiac muscle is similarly affected by dystrophin‐deficiency. We tested FA profiles in PL and triacylglycerol (TAG) in cardiac muscle of 12‐week old mdx and control (con) mice. Of 22 different FA, similar to our previous finding for skeletal muscle, the most abundant FA in heart PL were palmitic, stearic, cis ‐vaccenic, linoleic, and docosahexaenoic acid, while for TAG the most abundant FA were palmitic, oleic, cis ‐vaccenic, and linoleic acid. In comparing mdx and con, no significant group differences were detected for any FA in PL or TAG. Thus, unlike skeletal muscle, FA composition in cardiac muscle PL is not different between mdx and con at the age studied. The results can be understood in the context of tissue‐specific disease severity in mdx mice, as pathology is quite modest in cardiac compared with skeletal muscle.