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Down‐Regulation of Hepatic Stearoyl‐CoA Desaturase‐1 Expression by Fucoxanthin via Leptin Signaling in Diabetic/Obese KK‐ A y Mice
Author(s) -
Beppu Fumiaki,
Hosokawa Masashi,
Yim MiJin,
Shinoda Taro,
Miyashita Kazuo
Publication year - 2013
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-013-3784-4
Subject(s) - fucoxanthin , leptin , medicine , stearoyl coa desaturase , endocrinology , chemistry , sterol regulatory element binding protein , fatty acid , biochemistry , carotenoid , obesity , biology , gene expression , gene
Stearoyl‐coenzyme A desaturase‐1 (SCD1) is a rate‐limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. Recently, SCD1 down‐regulation has been implicated in the prevention of obesity, and the improvement of insulin and leptin sensitivity. In this study, we examined the effect of fucoxanthin, a marine carotenoid, on hepatic SCD1 in obese mouse models of hyperleptinemia KK‐ A y and leptin‐deficiency ob/ob . In KK‐ A y mice, providing a diet containing 0.2 % fucoxanthin for 2 weeks markedly suppressed SCD1 mRNA and protein expressions in the liver. The fatty acid composition of liver lipids was also affected by an observed decrease in the ratio of oleic acid to stearic acid. Furthermore, serum leptin levels were significantly decreased in hyperleptinemia KK‐ A y mice after 2 weeks of fucoxanthin feeding. However, the suppressive effects of fucoxanthin on hepatic SCD1 and body weight gain were not observed in ob/ob mice. These results show that fucoxanthin down‐regulates SCD1 expression and alters fatty acid composition of the liver via regulation of leptin signaling in hyperleptinemia KK‐ A y mice but not in leptin‐deficient ob/ob mice.