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Sphingolipid Content in the Human Uterus and Pair‐Matched Uterine Leiomyomas Remains Constant
Author(s) -
Paweł Knapp,
Chabowski Adrian,
Górski Jan
Publication year - 2013
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1007/s11745-012-3746-2
Subject(s) - ceramide , sphingosine , sphingolipid , sphingosine 1 phosphate , uterus , uterine leiomyoma , pten , mapk/erk pathway , endocrinology , medicine , lipid signaling , biology , microbiology and biotechnology , protein kinase b , chemistry , phosphorylation , signal transduction , pi3k/akt/mtor pathway , biochemistry , apoptosis , receptor
In the present work we sought to investigate the content of sphingolipids (sphingosine, sphinganine, sphingosine‐1‐phosphate and ceramide) in human fibroids and pair‐matched healthy uterus tissue. We demonstrated that, in uterine leiomyomas, the contents of sphingosine, sphinganine, sphingosine‐1‐phosphate and ceramide remains quite constant. However, a trend towards elevation of ceramide and simultaneous reduction of sphingosine‐1 phosphate levels was also noticed. Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF‐1α/AMPK activation. In conclusion, rather modest changes in sphingolipids are correlated with the activation of PTEN and MAPK(ERK1/2) signaling proteins in human uterine leiomyomas.